Principal Product Manager, Core AI

Twin Health

At Twin Health, we empower people to improve and prevent chronic metabolic diseases, like type 2 diabetes and obesity, with a new standard of care. Twin Health is the only company applying AI Digital Twin technology exclusively toward metabolic health.

We start by building a dynamic model of each person’s metabolism — drawing on thousands of data points from CGMs, smartwatches, and meal logs — that maps their personal path to better health. Guided by a dedicated clinical care team, our members have lowered their A1C below the diabetes range, achieved lasting weight loss, and reduced or even eliminated medications, all while living healthier, happier lives.

Working here

Our team at Twin Health is passionate, talented, and united by a shared purpose: to improve the metabolic health and happiness of our members. We believe in empowering every Twin to make a meaningful impact for our members, our clients, and each other, while enjoying a supportive, collaborative work environment.

Twin has been recognized not only for our innovation but also for our culture, including: Innovator of the Year by the Employer Health Innovation Roundtable (EHIR), selected to CB Insights’ Digital Health 150, and named one of Newsweek’s Top Most Loved Workplace® .

With more than $100 million raised in recent funding, including a $53 million Series E round in 2025 led by Maj Invest, and a $50 million investment in 2023 led by Temasek, Twin is scaling rapidly across the U.S. and globally. Backed by leading venture firms like ICONIQ Growth, Sequoia, Sofina, Temasek, and Peak XV, we are building the most impactful digital health company in the world.

Join us as we reinvent the standard of care in metabolic health.

Opportunity

We are building a new interface to health: the Digital Twin.

The Digital Twin is a living, real-time model of each member’s metabolism and behavior—continuously learning from sensors, meals, sleep, movement, labs, and daily choices. It detects patterns, anticipates what’s coming, and guides members toward better health through timely, personalized actions.

To the member, it feels like a single, ever-present guide.

Under the hood, it’s a coordinated system of AI agents and human care working as one.

We’re looking for a Principal Product Manager to help define and build the core intelligence system at the heart of Twin.

This role sits at the intersection of

LLMs and agent systems

Human + AI orchestration

Real-time health guidance

Voice and conversational interfaces

Platform and developer ecosystems

You will

Define how the Digital Twin behaves across text, voice, and proactive experiences Build specialized sub-agents that plug into the core Digital Twin Create the platform and primitives that enable teams across Twin to build agents safely and quickly Push the boundaries of what’s possible with modern AI systems in healthcare

Responsibilities

Define the Digital Twin intelligence system Translate the core loop—Sense → Understand → Decide → Act → Learn—into a scalable agent system Define how the Digital Twin reasons, responds, escalates, and coordinates across experiences Shape the future of AI-driven health guidance across text, voice, and proactive interactions Build specialized agent systems

Sensor intelligence

Scheduling and coordination

Nutrition

Exercise, sleep, and stress

Insights

App help and operational support

Care-team interaction orchestration

Build the platform that enables the company Create the foundations that allow PMs and teams to build on top of the Digital Twin Establish primitives for:

Agent creation and orchestration

Memory and personalization

Evaluation and monitoring

Define next-generation conversational experiences Build deeply personalized experiences across chat, two-way voice, and ambient guidance Define conversation patterns and interaction models that feel natural, trusted, and useful Operate at frontier speed Rapidly move from insight → prototype → experiment → production Partner deeply with AI Engineering, Design, Clinical, and Product teams Continuously evaluate emerging capabilities across LLMs, speech, memory, and agent systems Establish metrics and evaluation systems for:

Guidance quality

Conversation effectiveness

Problem resolution

Behavior change

Other duties as assigned.

Qualifications

8+ years in Product Management (or equivalent impact), including significant experience building AI-native products 3+ years building and shipping products powered by:

LLMs

Agents

RAG

Personalization systems

Track record of owning complex, system-level products Experience shipping conversational or voice experiences with measurable impact Strong product judgment and analytical instincts:

Experimentation

Evaluation design

KPI definition

Builder mindset—you move from concept to shipped system quickly

Compensation and Benefits

The compensation range for this position is $205,000 - $240,000 annually.

Twin has an ambitious vision to empower people to live healthier and happier lives, and to achieve this purpose, we need the very best people to enhance our cutting-edge technology and medical science, deliver the best possible care, and turn our passion into value for our members, partners and investors.

We are committed to delivering an outstanding culture and experience for every Twin employee through a company based on the values of passion, talent, and trust. We offer comprehensive benefits and perks in line with these principles, as well as a high level of flexibility for every Twin A competitive compensation package in line with leading technology companies A remote and accomplished global team Opportunity for equity participation Unlimited vacation with manager approval 16 weeks of 100% paid parental leave for delivering parents; 8 weeks of 100% paid parental leave for non-delivering parents 100% Employer sponsored healthcare, dental, and vision for you, and 80% coverage for your family; Health Savings Account and Flexible Spending Account options 401k retirement savings plan Salary range for US jobs

US Salary Range

$205,000—$240,000 USD

We have been made aware of fraudulent interview requests being sent using the Twin Health's name. All communications will come from official Twin Health channels and a twinhealth.com email address. We will never ask you to complete a text interview or request financial details during the interview process.